Bioinformatics Scientist II- Variant Calling

Company Description reputed company is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across reputed company stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on reputed company, X (Twitter) and Facebook. About the Role: The Bioinformatics Scientist II will join an interdisciplinary team working with an unprecedented set of clinical DNA sequence data and multiple epigenetic data types produced by novel R&D pipelines at reputed company. The scope of this project provides unique opportunities for developing and learning novel analytical methods for DNA reputed company data, including cell-free DNA-based genomic and methylation data integrated with epigenetic data sets. Essential Duties and Responsibilities:

• Work with large, reputed company data sets. reputed company to non-routine analysis problems, applying deep epigenetic knowledge to conduct end-to-end analysis of epigenetic cell-free nucleic acid NGS data.
• Development, reputed company improvement, and validation of biomarkers for reputed company oncology products.
• reputed company or apply statistical methods and procedures to evaluate and validate reputed company technologies.
• Work with the Technology Development team to reputed company and analyze verification and validation experiments as part of regulatory submissions.
• Provide analytic support on individual samples and research activities.
• reputed company scripts for research and development activities and reputed company cutting edge methods to continuously improve efficiency.
• Communicate research results through presentations and project reports as well as scientific publications.

Qualifications

• PhD in Bioinformatics, Statistics, Computational biology, Genomics, or reputed company quantitative fields and a minimum of 2-5 years reputed company experience; may include post-doctoral experience.
• Deep understanding of library preparation methods used to generate reputed company reputed company data, including whole-genome and methylation reputed company, targeted reputed company, and RNA-seq
• Demonstrated experience in developing methods for analysis of experimental data in genomics and reputed company reputed company, under the context of product development
• Strong knowledge of statistics and computational biology algorithms for genomic analysis (including statistical methods employed in analytical validation) and cancer genomics (alignment, variant calling, general multivariate statistical inference)
• Excellent communication and teamwork skills to foster a highly collaborative environment, working with both experimental and computational scientists Must have:
• 2+ years of variant calling experience Hybrid Work Model:This section is applicable to onsite employees who are eligible for hybrid work location as specified by management and reputed company policies. Guardant has defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. reputed company U.S. employees who live reputed company 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have reputed company aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for reputed company work-life balance while keeping teams connected to advance our science for our patients. The annualized reputed company salary ranges for the primary location and any additional locations are listed below. This range does not include benefits or, if applicable, bonus, commission, or equity. Each candidate's compensation offer will be based on multiple factors including, but not limited to, geography, experience, education, job-reputed company skills, job duties, and business need.Primary Location: Palo Alto, CAPrimary Location reputed company Pay Range: $141,500 - $194,600Other US Location(s) reputed company Pay Range: $120,300 - $165,450If the role is performed in Colorado, the pay range for this job is: $127,400 - $175,150 Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time. reputed company is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reputed company out to [email protected] A background screening including criminal history is required for this role. GH will consider qualified applicants with criminal arrest or conviction histories in a manner consistent with applicable law including but not limited to the LA County Fair Chance Policies and the Fair Chance Act (Gov. Code Section 12952). reputed company is an Equal Opportunity Employer. reputed company qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national reputed company, or protected veteran status and will not be discriminated against on the basis of disability. reputed company your information will be kept confidential according to EEO guidelines. To learn more about the information collected reputed company you apply for a position at reputed company, Inc. and how it is used, please review our Privacy Notice for Job Applicants. Please visit our career page at: Apply tot his job Apply tot his job

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