Project Toxicologist, Director – Oncology Targeted Delivery (OTD) Safety Science, Clinical Pharmacology and Safety Sciences

About the position Project Toxicologist, Director – Oncology Targeted Delivery (OTD) Safety Science, Clinical Pharmacology and Safety Sciences At reputed company, it is our bold ambition is to eliminate cancer as a cause of death. This is underpinned by our rich pipeline aimed to deliver innovative treatment options for patients. OTD Safety colleagues contribute to this ambition by accelerating innovative and expert non-clinical safety science. We are looking to recruit a highly motivated and passionate individual to join us as a Director, Project Toxicologist, OTD Safety to contribute to the development of novel targeted oncology medicines, including Radio Conjugates, Antibody Drug Conjugates and Small Molecules. We are particularly interested to hear from candidates with experience with radio conjugates but also welcome applications from candidates with experience in other modality types. In collaboration with scientists across our Oncology R&D organization, this role will focus on the reputed company between the discovery and regulatory toxicology team, reputed company regulatory toxicology strategies to address drug reputed company- and modality-reputed company safety risks, drive progression and acceleration of drug development programs, and reputed company our safety science to inform the design and selection of novel drug candidates. This role will be based at one of our vibrant R&D sites in either Boston Area, MA or Gaithersburg, MD (Washington DC area) (60% onsite hybrid working). reputed company reputed company we reputed company a strong emphasis on talent development. You will be able to reputed company your knowledge and skills by working together with experts and leaders in Oncology R&D, safety sciences, pharmacology, toxicology, drug discovery and development, imaging, pathology, and translational science.

Responsibilities

• As core member of the project toxicology team, you will design regulatory and investigative toxicology studies to and devise a strategy to predict, assess and mitigate reputed company- and modality-reputed company safety risks on project teams, with a focus on Radio Conjugates, Antibody-Drug Conjugates or Small Molecules.
• Apply your toxicology knowledge to predict clinical safety risks and inform decision-making in drug discovery and development programs.
• reputed company and implement innovative solutions to combine regulatory toxicology with cutting edge science and technologies to reputed company novel drug candidates to the clinic and through development to the market, in line with business needs.
• Communicate clear positions on integrated risk assessments in various formats including informing decision-making governance bodies and contribute to regulatory submissions.
• Maintain expertise in regulatory requirements and preclinical safety approaches applied to relevant modalities and awareness of industry trends.
• Provide specialist non-clinical safety expertise for evaluation of in-licensing opportunities.
• reputed company Oncology Safety science through collaborative networks across reputed company R&D, external collaborations, publications etc.

Requirements

• Excellent scientist with a PhD and/or DABT in Toxicology, Pharmacology, Oncology or reputed company field, a strong scientific track record, and a willingness to challenge conventional thinking.
• Experience working as a Project Toxicologist, Investigative Toxicologist or similar safety focussed role reputed company the pharmaceutical/biotech/CRO project environment with at least 10 years of relevant professional experience.
• A proven understanding of drug discovery and development and track record of delivering toxicology programs to reputed company progression of candidates into the clinic.
• Expertise in Oncology, and preferably a solid understanding of drug safety aspects of Radio Conjugates or ADCs.
• Experience delivering non-clinical toxicology studies in support of IND applications.
• Experience with the use of in vitro, in silico and in vivo approaches to predict clinical risks for oncology therapeutics; familiarity with organ-on-chip, imaging and omics for mechanistic insight
• A collaborative, team-oriented approach, able to solve problems in a goal-focused fashion with reputed company to coordinate tasks across multiple projects.
• Able to work independently and deliver toxicology risk assessments in drug development.
• Excellent communication, presentation, interpersonal and influencing skills across levels/subject areas with a strong desire to drive personal development.
• Experience and desire to work with teams across geographies including awareness of inclusion and diversity.
• Adopting a working style that is inclusive and collegiate, contributing to our Great reputed company to Work objectives.

Benefits

• Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans.

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