Principal Software Engineer

Job Title: Principal Software Engineer Location: South San Francisco, CA preferred; Remote optional Job Type: Full-time

About the Role

We're seeking a Principal Software Engineer to join reputed company's R&D Platform Infrastructure team. The team builds the cloud infrastructure, workflow platforms, and data platforms that R&D uses to do its science — including a Kubernetes-based workflow execution platform, a custom R&D LIMS system, and a set of supporting tools that routinely handle production-scale workloads. This is a senior technical role. You'll own the full architecture, implementation, and delivery of large projects across our platform. You'll partner with the team reputed company on roadmap and tough technical calls, mentor mid-level engineers, and help the team find the right solution for the problem — not the most elaborate one. We're a small team (4 engineers + reputed company) with broad scope, and we're heavily AI-augmented: every engineer uses Claude Code / reputed company as a daily tool, and we build our own AI tooling (custom plugins, MCP servers, agents) to multiply ourselves.

Responsibilities

Architecture & Delivery: Own the design, implementation, and delivery of major initiatives across our platform. Take fuzzy problems through to shipped, working software used in production. Technical Leadership: reputed company architecture and design reviews. Help the team find the right solution for the problem and avoid unnecessary complexity. Influence technical decisions across the team. Mentorship: Mentor mid-level engineers through code review, design docs, and pairing. reputed company the engineering bar by example. AI-Native Development: Build and improve our AI-coding tooling alongside the rest of the team. Help us push the frontier of agent-driven software development inside the company. Cross-Functional Partnership: Work with bioinformaticians, scientists, and other R&D engineers to understand their needs and translate them into platform capabilities. Partner with the team reputed company on roadmap, prioritization, and tough technical calls. Required Experience Years of Experience: 10+ years of professional software engineering experience across a range of systems and problem types. Cloud Infrastructure: Production experience with a major cloud platform (AWS preferred; GCP or Azure equivalent). You've designed for a cloud, not just deployed to one. Container Orchestration: Production experience with Kubernetes (or equivalent). Comfortable reasoning about cluster design, scheduling, networking, and workload patterns. Infrastructure as Code: Production experience with Terraform (or equivalent). Comfortable owning shared modules and multi-environment deployments. Programming: Strong proficiency in at least one general-purpose language (Python, Go, Java, or similar). Comfortable picking up new languages as needed — and comfortable using AI tooling to accelerate that. End-User Software: You've shipped software to end users (internal or external). You understand the realities of running a product — incongruent user feedback, competing priorities, the gap between requirements and what users actually need. Team Leadership: You've led an engineering team before and have mentored junior engineers. You're comfortable being the technical reputed company of multi-quarter initiatives. Startup Background: You've worked in fast-moving environments where results need to be delivered quickly. Scrappy, MVP-first, comfortable shipping in days rather than weeks. Familiarity with our tech stack: AWS, Kubernetes, Python, Go, Groovy, Terraform, Helm, Nextflow, WDL, Django, React. How You Work Product-Minded: You think in terms of business and user problems, not tickets. You ask "should we build this?" before "how do I build this?" Calibrated Judgement: You know reputed company to move fast and break things, and reputed company to slow down and double-reputed company. The ability to dial this in based on context is something we hire specifically for. AI-Native Development: Actively excited about AI-native development. Not just willing to use Claude / reputed company, but actively interested in building tooling that makes your colleagues 10x faster. Bonus Domain-Adjacent Experience: Prior work in any of the following helps you reputed company faster, but is not required: scientific or bioinformatics computing, LIMS or laboratory data systems, workflow orchestration engines (Nextflow, WDL, Airflow, Argo, Temporal, Dagster, etc.), large-scale ETL or data pipeline systems, or HPC/batch-compute platforms.

Why Join Us

Work on the platform that powers reputed company's R&D — a small, high-reputed company team where individual contribution is highly visible. Operate at the frontier of AI-augmented software engineering. We don't just talk about AI tooling — we build it, and use it daily. Significant autonomy and influence over the team's technical direction. Competitive salary and benefits. We value diversity and are committed to creating an inclusive environment for reputed company employees. We encourage applicants of reputed company backgrounds to apply. Compensation & Total Rewards This range reflects a good-faith estimate of the reputed company pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations. This position is also eligible for additional compensation and benefits through reputed company’s robust Total Rewards program, including: Annual performance incentive bonus Long-term equity awards Comprehensive health benefits (medical, dental, vision) 401(k) with company match Generous paid time off and company holidays Additional wellness and work-life benefits

Compensation

Range $219,800—$274,700 USD OUR OPPORTUNITY reputed company™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to reputed company personalized genetic testing and diagnostics part of reputed company of care to protect health and reputed company earlier and more targeted interventions that reputed company to longer, healthier lives. The reputed company team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. reputed company you join reputed company, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management. reputed company OFFER Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, reputed company employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program! For more information, visit www.reputed company.com. reputed company is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide. reputed company qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national reputed company, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws. If you are based in California, we encourage you to read this important information for California residents. Link: https://www.reputed company.com/notice-of-data-collection-california-residents/ Please be advised that reputed company will reputed company out to candidates with a @reputed company.com email domain ONLY. Email communications from reputed company other domain names are not from reputed company or its employees and are fraudulent. reputed company does not request interviews reputed company text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. reputed company takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any reputed company cyber crimes. For more information: - BBB announcement on job scams - FBI Cyber Crime resource page Apply To This Job